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Steer clear of coadministration of ganaxolone with reasonable or solid CYP3A4 inducers. If coadministration unavoidable, take into consideration rising ganaxolone dose; even so, tend not to exceed optimum day-to-day dose for weight.pentobarbital will decrease the extent or impact of apremilast by affecting hepatic/intestinal enzyme CYP3A4 metabolis